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Future research should prioritize the diagnostic and therapeutic potential of immune-inflammatory biomarkers in ASD, and explore precision treatments targeting specific cytokines or inflammatory pathways, paving the way for personalized medical approaches (Figure 1)

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Instead, it acts through hypothalamic thermoregulation, gently lowering core body temperature before sleep onset.¹ Clinical studies demonstrate that individuals taking 3 grams approximately one hour before bedtime frequently experience: Faster sleep onset Improved sleep efficiency Better REM sleep architecture Reduced daytime fatigue Improved cognitive performance the following morning¹˒² This mechanism closely resembles the natural physiologic temperature decline that precedes restorative sleep